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NEXT: Meet Lena’s Infamous Brother Lex Luthor (Jon Cryer) on Sunday’s SUPERGIRL

Supergirl Season 4.

Updated with new teaser:

We meet Lena (Katie McGrath)’s brother Lex Luthor (Jon Cryer) on the next Supergirl, O Brother Where Art Thou?

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JON CRYER GUEST STARS AS ICONIC DC COMICS’ VILLAIN LEX LUTHOR —Secretly furloughed from prison due to failing health, Lex Luthor (Jon Cryer) visits his sister, Lena (Katie McGrath), to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex’s motives but when she’s faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl (Melissa Benoist) and J’onn (David Harewood) face off against Manchester Black (David Ajala). James’ sister Kelly (Azie Tesfai) comes to town. Tawnia Mckiernan directed the episode written by Derek Simon & Nicki Holcomb.

Superman’s sworn enemy.

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Related: First Look at Jon Cryer as Lex Luthor on Supergirl.

First official look at Jon Cryer as Lex Luthor.

Related: Jon Cryer Cast as Villainous Lex Luthor on Supergirl.

I think that he’s the biggest supervillain we’ve had the show, and his plans will kind of touch every character and impact the entire season moving forward once he arrives.– co showrunner Robert Rower told EW.

Cryer played Lex Luthor’s nephew Lenny in the 1987 movie Superman IV: The Quest for Peace.

We are enormous fans of Jon Cryer, and he was instantly our dream actor to play the iconic role of Lex Luthor. Jon is a super-talent, and the fact that he played Lenny Luthor in Superman IV brings an added layer of legacy to his casting. We’re beyond thrilled to welcome Jon to the Supergirl family. — Co-Showrunners Robert Rovner and Jessica Queller.

Superfan Joe D’Aquisto ran into Jon Cryer at the airport.

Lex Luthor debuts on Supergirl’s March 17th episode.